BRAFV600E Mutation and Papillary Thyroid Cancer—In Reply
نویسندگان
چکیده
منابع مشابه
Clinical implication of the BRAFV600E mutation in papillary thyroid carcinoma
BACKGROUND The BRAFV600E mutation is the most common genetic alteration in papillary thyroid carcinoma (PTC). In recent studies, the BRAFV600E mutation has been associated with poor clinicopathological characteristics, such as lymph node metastasis, extrathyroidal extension, and advanced stage. However, other studies have failed to establish an association between the BRAFV600E mutation and cli...
متن کاملThyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status.
Resistance to thyroid hormone (RTH) is a rare autosomal dominant hereditary disorder. Here in, we report two patients with RTH in whom differentiated thyroid cancer was diagnosed. Two patients were admitted to our clinic and their laboratory results were elevated thyroid hormone levels with unsuppressed TSH. We considered this situation thyroid hormone resistance in the light of laboratory and ...
متن کاملThe relationship between the BRAFV600E mutation in papillary thyroid microcarcinoma and clinicopathologic factors
BACKGROUND The BRAF(V600E) mutation, which accounts for about 60-80% papillary thyroid carcinoma(PTC), has been identifiedas a prognostic marker for risk stratification of PTC patients. However, the BRAF(V600E) mutation as a prognostic marker in papillary thyroid microcarcinoma (PTMC) is unclear. METHODS We performed a retrospective review of 101 patients who underwent surgery for PTMC. We st...
متن کاملAssociation between BRAFV600E mutation and the clinicopathological features of solitary papillary thyroid microcarcinoma
The B-Raf proto-oncogene serine/threonine kinase (BRAF)V600E mutation is an important oncogene in the development of papillary thyroid carcinoma (PTC) and has been identified as a risk factor for poor prognosis in patients with PTC. However, whether the BRAFV600E mutation is a prognostic marker in patients with solitary papillary thyroid microcarcinoma (sPTMC) has not yet been established. The ...
متن کاملBRAFV600E mutation contributes papillary thyroid carcinoma and Hashimoto thyroiditis with resistance to thyroid hormone: A case report and literature review
Resistance to thyroid hormone (RTH) is a rare autosomal hereditary disorder characterized by increased serum thyroid hormone (TH) levels with unsuppressed or increased thyrotropin concentration. It remains unknown whether the coexistence of RTH with papillary thyroid carcinoma (PTC) and Hashimoto thyroiditis (HT) is incidental or whether it possesses a genetic or pathophysiological association....
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ژورنال
عنوان ژورنال: JAMA
سال: 2013
ISSN: 0098-7484
DOI: 10.1001/jama.2013.8598